Randomized Trialhigh evidence
Totum-63, a plant-based polyphenol-rich extract, in prediabetes or early-stage type 2 diabetes: an international, multicenter, randomized controlled trial.
Nature communications·July 20, 2026·PMID 42477326
Why it mattersIdentifying safe, plant-based interventions that modestly improve fasting glucose could expand the toolkit for managing prediabetes and early diabetes, particularly for patients seeking non-pharmacologic options or adjuncts to lifestyle modification.
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