Randomized Trialhigh evidence
Periarticular Injection Alone Provides Comparable Early Recovery to Combined Adductor Canal and Infiltration between the Popliteal Artery and Capsule of the Knee Blocks Following Total Knee Arthroplasty: A Prospective Randomized Trial.
The Journal of arthroplasty·July 28, 2026·PMID 42520994
Why it mattersMultimodal analgesia protocols for total knee arthroplasty often include regional blocks, but their added benefit over a robust periarticular injection is unclear. This study suggests that routine use of ACB and IPACK blocks may not improve recovery beyond PAI alone, potentially simplifying perioperative pain management and reducing procedural time and costs.

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