Randomized Trialhigh evidence
A Multidomain Lifestyle Intervention for Invasively Confirmed ANOCA: The SAMCRO Randomized Trial.
JACC. Cardiovascular interventions·July 27, 2026·PMID 42508842
Why it mattersANOCA causes persistent symptoms and impaired quality of life despite non-obstructive coronaries, and randomized evidence for lifestyle interventions has been lacking. This trial provides high-level evidence that a structured, multidomain lifestyle program added to endotype-guided therapy yields large, clinically meaningful improvements in patient-reported outcomes.
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