Meta-Analysishigh evidence
Effect of testosterone replacement therapy on fracture risk in hypogonadal men: A systematic review and meta-analysis of randomized controlled trials.
Maturitas·June 1, 2026·PMID 42066666
Why it mattersWhile TRT is known to improve bone mineral density, its effect on fracture risk has been uncertain. This analysis suggests a potential increase in overall clinical fractures, which may influence risk-benefit discussions when prescribing TRT for hypogonadal men, especially those at higher fracture risk.
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