Meta-Analysismoderate evidence
NSAID Use and Bone Healing: An Umbrella Review with a Reconstructed Meta-Analysis.
The Journal of the American Academy of Orthopaedic Surgeons·July 21, 2026·PMID 42489592
Why it mattersNSAIDs are a mainstay of perioperative analgesia, yet their effect on bone healing has been controversial. This analysis clarifies that risk is not uniform—it depends on patient age, fracture type, dose, and duration—helping clinicians tailor analgesic choices to balance pain control and healing outcomes.
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